An overview of topical ophthalmic drugs and the therapeutics of ocular infection

Pharmacokinetics, is by definition, the study of the time and dosage relationships of administered drugs. When considering pharmacokinetics one must assume fictional body spaces between which drugs pass, and within which drugs are equally distributed. In the systemic sense these spaces include the intravascular compartment the extracellular spaces and the intracellular spaces. However, for the purposes of ocular pharmacokinetics, we are more concerned with the ocular compartments, which comprise a) the tear film and cul-de-sac, b) the anterior chamber, c) the vitreous cavity and d) the retro or periocular space (obviously these compartments can be subdivided but this is unnecessary for the purposes of this review).